Journal: British Journal of Clinical Pharmacology

Article Title: The impact of CES1 genotypes on the pharmacokinetics of methylphenidate in healthy Danish subjects

doi: 10.1111/bcp.13237

Figure Lengend Snippet: Pharmacokinetic parameters on a group level

Article Snippet: Analytical method d,l‐Threo ‐methylphenidate was sourced from Lipomed (Arlesheim, Switzerland), d,l‐threo ‐ritalinic acid was from Novartis (Basel, Switzerland), while internal standards d,l‐threo ‐methylphenidate‐d10 and d,l‐threo ‐ritalinic acid‐d10 were from Toronto Research Chemicals (Toronto, Canada).

Techniques:

Journal: Food Science & Nutrition

Article Title: Rice Bran Supplements the Nutritional Density of Ready‐to‐Use Therapeutic Foods: A Targeted Nutrient and Non‐Targeted Metabolomic Analysis

doi: 10.1002/fsn3.71448

Figure Lengend Snippet: Non‐targeted metabolomic analysis of the experimental RUTFs. (A) Total of median scaled relative abundance metabolites within chemical classes for each RUTF ( n = 3) with different doses of rice bran. (B) Principal component analysis (PCA) of metabolites in 0% rice bran‐RUTF ( n = 3), 5% rice bran‐RUTF ( n = 3), 7.5% rice bran‐RUTF ( n = 3), and 10% rice bran‐RUTF ( n = 3). (C) Top‐ranked 25 variable importance in projection (VIP) scores based on partial least squares‐discriminant analysis (PLS‐DA). VIP score reflects a measure for metabolite impact as a discriminant feature among the RUTFs.

Article Snippet: Within the chemical class of Xenobiotics, many compounds responsible for distinctions between the different rice bran RUTF doses compared to no rice bran were phytochemicals such as ferulic acid metabolites (feruloylquinate and feruloylputrescine) and salicylate‐glucoside (Figure ).

Techniques: Metabolomic

Journal: Food Science & Nutrition

Article Title: Rice Bran Supplements the Nutritional Density of Ready‐to‐Use Therapeutic Foods: A Targeted Nutrient and Non‐Targeted Metabolomic Analysis

doi: 10.1002/fsn3.71448

Figure Lengend Snippet: Select metabolite fold differences of log‐transformed median scaled relative abundance in comparison to 0% rice bran‐RUTF. Metabolites were selected based on top VIP scores for the chemical classes (A) Lipids, (B) Amino Acids, (C) Carbohydrates, (D) Cofactors and Vitamins, and (E) Xenobiotic compounds. Welch's t ‐tests were used to determine statistical significance. The unadjusted p ‐value is shown as * p ≤ 0.05; ** p ≤ 0.01; *** p ≤ 0.001, **** p ≤ 0.0001.

Article Snippet: Within the chemical class of Xenobiotics, many compounds responsible for distinctions between the different rice bran RUTF doses compared to no rice bran were phytochemicals such as ferulic acid metabolites (feruloylquinate and feruloylputrescine) and salicylate‐glucoside (Figure ).

Techniques: Transformation Assay, Comparison